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胃癌在世界范围内发病率高,死亡率也高,近些年肠型胃癌发病率有所下降,但弥漫型胃癌发病率不降反升。已知上皮型钙黏蛋白(E-cadherin,E-cd)与肿瘤的发生、侵袭和转移有关。E-cd胚系突变是遗传性弥漫型胃癌发病的遗传学基础,散发性弥漫型胃癌中常见其表达下调,但其下调的临床病理意义尤其是预后意义仍无定论。本文对E-cd在散发性弥漫型胃癌的表达情况及其下调机制进行了综述。
The incidence of gastric cancer in the world high mortality is also high, in recent years, the incidence of intestinal type gastric cancer decreased, but the incidence of diffuse gastric cancer rose without falling. E-cadherin (E-cd) is known to be involved in tumorigenesis, invasion and metastasis. E-cd germline mutation is the genetics basis of hereditary diffuse type gastric cancer. The expression of E-cd germline mutation is often downregulated in diffuse type gastric cancer, but the clinicopathological significance, especially prognostic significance, remains undetermined. This article reviews the expression of E-cd in sporadic diffuse gastric cancer and its down-regulation mechanism.