论文部分内容阅读
在部分西方国家,糖尿病已成为慢性肾脏病(CKD)和终末期肾脏病(ESRD)的主要原因,糖尿病进展为终末期肾病的比例在我国也逐渐上升,目前仅次于肾小球肾炎位列第二。关于糖尿病ESRD患者的血糖管理主要参照肾功能正常的糖尿病指南,但肾功能减退会使糖代谢和胰岛素代谢以及药物动力学发生显著变化,因此在治疗过程中,使糖尿病ESRD的血糖控制变得更为棘手。一、糖尿病ESRD的严峻形势据估计,美国2010年的CKD5期患者将达到50万,
Diabetes mellitus has become a major cause of chronic kidney disease (CKD) and end-stage renal disease (ESRD) in some western countries. The proportion of patients with diabetes that progress to end-stage renal disease also rises gradually in our country, currently ranking second only to glomerular nephritis second. With regard to glycemic management in patients with diabetes mellitus, ESRD mainly refers to the guidelines for diabetes with normal renal function, but renal dysfunction causes significant changes in glucose metabolism and insulin metabolism as well as pharmacokinetics, thus making glycemic control of diabetic ESRD more likely during treatment Thorny. First, the severe situation of diabetes ESRD It is estimated that the United States in 2010 CKD5 patients will reach 500,000,