脑卒中以缺血性脑卒中最为多见,脑血管阻塞,导致脑组织损伤继而引起神经功能障碍是其发生的主要原因。脑卒中是导致人类残疾甚至死亡的主要原因之一,严重威胁着人类健康,而其治疗却仍然是一个难题。为了研究脑卒中的发病机制,更好地预防和治疗脑卒中,建立合适的动物模型至关重要。然而,随着科学技术的更新,传统脑缺血模型的局限性日益凸显,多种新型脑缺血模型如原位注射凝血酶、局部应用FeCl_3模型应运而生。文中就目前脑缺血动物模型的适用范围、优缺点进行综述。 Stroke ischemic stroke is the most common, cerebral vascular obstruction, leading to brain tissue damage and subsequent neurological dysfunction is the main reason for its occurrence. Stroke is one of the major causes of human disability or even death, which seriously threatens human health. However, its treatment is still a difficult problem. In order to study the pathogenesis of stroke and to better prevent and treat stroke, it is of crucial importance to establish a suitable animal model. However, with the renewal of science and technology, the limitations of the traditional cerebral ischemia model have become increasingly prominent. Many new models of cerebral ischemia, such as in situ injection of thrombin, have emerged as the topical application of the FeCl_3 model. In this paper, the current application of the animal model of cerebral ischemia, advantages and disadvantages are reviewed.