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目的 :观察用左旋门冬酰胺酶 (L- ASP)治疗儿童急性淋巴细胞性白血病时引起的胰腺毒副作用及转归。方法 :用 VDL P方案治疗 12 8例 ,定期做血尿淀粉酶及血尿糖 (尿酮 )检测。结果 :8例 (6 .0 3% )出现胰腺毒副作用 ,年龄 9岁～ 13岁 ,均发生在诱导缓解治疗期 ,急性胰腺炎 5例 ,继发糖尿病 7例 (3例伴酮症酸中毒 ) ;4例上述两者并存。结论 :L- ASP引起的胰腺毒副作用与患儿年龄及个体敏感差异有关 ,与药物累积剂量及性别无关。急性胰腺炎和继发糖尿病可分别发生 ,也可在同一个体中出现
Objective: To observe the side effects and prognosis of pancreatic induced by L-asparaginase (L-ASP) in children with acute lymphoblastic leukemia. Methods: 128 cases were treated with VDL P regimen, and hematuria amylase and hematuria (urine ketone) were tested regularly. Results: Eight patients (6.30%) had pancreatic side effects, ranging in age from 9 to 13 years. All of them occurred in the course of inducing remission. There were 5 cases of acute pancreatitis, 7 cases of secondary diabetes mellitus (3 cases with ketoacidosis ); 4 cases of the two co-exist. Conclusion: The side effects of pancreatic cancer induced by L-ASP are related to the differences in children’s age and individual sensitivity, but not with the cumulative dose and sex of the drug. Acute pancreatitis and secondary diabetes can occur separately, but also in the same individual