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对Ⅱ型糖尿病病人已采用磺脲类、双胍类联合治疗仍不能有效控制高血糖时 ,加用阿卡波糖联合治疗 ,观察其疗效及安全性。方法 :随机选择该类病人 30例 ,在原治疗的基础上加用阿卡波糖 5 0mg ,1个月后改为 10 0mg ,tid ,12周为 1个疗程。结果 :治疗后患者空腹血糖及餐后 2h血糖明显下降 ,总有效率 5 6 .7% ,甘油三酯及胆固醇亦明显下降 ,而对血清胰岛素无明显影响。结论 :对Ⅱ型糖尿病病人已采用磺脲类、双胍类联合治疗仍不能有效控制高血糖时 ,加用阿卡波糖治疗 ,有 >5 0 %病人获得较好疗效 ,且副作用轻微。
For type II diabetes patients have been used sulfonylurea, biguanide combination therapy is still not effective in the control of hyperglycemia, combined with acarbose combination therapy to observe its efficacy and safety. Methods: Thirty patients were randomly selected on the basis of the original treatment with acarbose 50mg, 1 month later changed to 10mg, tid, 12 weeks for a course of treatment. Results: After treatment, fasting blood glucose and postprandial blood glucose 2h significantly decreased, the total effective rate of 56.7%, triglyceride and cholesterol also decreased significantly, but no significant effect on serum insulin. CONCLUSIONS: Acarbose is used in patients with type 2 diabetes who have been treated with sulfonylureas or biguanides for the treatment of hyperglycemia. More than 50% of the patients have good efficacy and mild side effects.