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目的 调查新生儿早发型母乳性黄疸发病情况及病因 ,观察吗丁啉、开塞露早期干预的效果。方法 对 1～ 4日龄新生儿 2 6 3例利用经皮胆红素测定仪观察黄疸变化 ,调查胎便排泄规律、哺乳习惯 ,以及与早发型母乳性黄疸相关性 ,分别应用吗丁啉口服、开塞露灌肠对 3日龄新生儿进行干预 ,观察其干预效果。结果 2～ 4日龄新生儿早发型母乳性黄疸发生率分别为 11.0 3%、2 2 .0 5 %、2 9.2 8%和 34.99%。首次排胎便时间 ,首次排黄便时间与早发型母乳性黄疸呈明显相关(r =0 .16 ,P <0 .0 1) ;而与开始喂母乳时间的相关性不明显。应用吗丁啉、开塞露干预的第 3日龄新生儿早发型母乳性黄疸的发病例数与对照组比较 ,均有显著性差异 (P <0 .0 1)。 结论 早发型母乳性黄疸的发病与胎便排泄延迟密切相关 ,应用吗丁啉、开塞露干预是有效的手段之一。
Objective To investigate the incidence and etiology of neonatal early-onset breast milk jaundice and to observe the effect of early intervention with domperidone and kaempferol. Methods The changes of jaundice were observed in 263 neonates with 1 ~ 4 days of age using transdermal bilirubin analyzer. The regularity of excretion of meconium, lactation habits and the relationship with premature breast milk jaundice were investigated. Open Cypriot dew enema on the 3-day-old newborn intervention to observe the intervention effect. Results The incidence of early-onset breast milk jaundice in neonates aged 2 to 4 days were 11.0 3%, 22.05%, 29.28% and 34.99%, respectively. The time of the first paw edema was significantly correlated with the time of the first maternal jaundice (r = 0.16, P <0.01), but not with the initial time of breastfeeding. The incidence of early-onset breast milk jaundice in the 3rd day old infant treated with domperidone and cyproalide was significantly lower than that in the control group (P <0.01). Conclusions The incidence of early-onset breast milk jaundice is closely related to the delay of excretion of meconium. One of the effective measures is the use of domperidone and Kaiseril.