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目的 :研究通脉酯注射剂 (赤芍 80 1)治疗急性脑梗死的疗效。方法 :随机选择急性脑梗死患者 6 0例(治疗组 ,静滴通脉酯注射剂 180 mg)和对照组 6 0例 (静滴复方丹参注射液 2 0 ml) ,两种药物均加入质量分数为 5 %的葡萄糖或 0 .9%氯化钠溶液 5 0 0 ml中 ,每日 1次 ,连用 14日。治疗组患者治疗前后做血液流变学、血糖、血脂、肝功能、肾功能、心电图检查。结果 :治疗组总有效率 (95 .0 % )明显优于对照组 (75 .0 % ) ,2组比较差异有显著性 (P<0 .0 1) ;通脉酯注射剂治疗前后神经功能缺损程度评分〔(19.2 3± 8.34)分 ,(5 .16± 6 .0 7)分〕及生活能力状态评分〔(4.2 6± 1.35 )分 ,(1.86± 1.77)分〕比较有显著性差异 (P均 <0 .0 1) ,与对照组〔治疗后分别为 (9.2 0± 7.19)分和 (2 .82± 1.83)分〕比较差异亦均有显著性 (P均 <0 .0 1) ;全血黏度、血浆黏度及血小板聚集率均较治疗前下降 ,差异均有显著性 (P均 <0 .0 1) ;而纤维蛋白原较治疗前略有下降 ,但差异无显著性(P>0 .0 5 ) ;未发现有明显不良反应。结论 :通脉酯注射剂 (赤芍 80 1)是治疗急性脑梗死安全有效的药物。
Objective: To study the effect of Tongmai ester injection (Paoshao 80 1) in the treatment of acute cerebral infarction. Methods: A total of 60 patients with acute cerebral infarction (treatment group, 180 mg intravenous infusion of collaterals injection) and 60 cases of control group (20 mL intravenous compound Danshen injection) were randomly selected. The two drugs were added 5% glucose or 0 .9% sodium chloride solution 500 ml once daily for 14 days. Patients in treatment group before and after treatment to do blood rheology, blood glucose, blood lipids, liver function, renal function, ECG. Results: The total effective rate (95.0%) in the treatment group was significantly better than that in the control group (75.0%), there was significant difference between the two groups (P0.01). The neurological deficits (19.2 3 ± 8.34), (5 .16 ± 6 .0 7) points, and viability score [(4.2 6 ± 1.35) points, (1.86 ± 1.77) points] were significantly different P <0.01), there were also significant differences between the two groups (9.2 ± 7.19 and 9.282 ± 1.83, respectively) after treatment (all P <0.01) ; Whole blood viscosity, plasma viscosity and platelet aggregation rate decreased compared with before treatment, the difference was significant (P all <0.01), while fibrinogen slightly decreased compared with before treatment, but the difference was not significant (P> 0 .0 5); no obvious adverse reaction was found. Conclusion: Tongmai injection (TP 1001) is a safe and effective treatment of acute cerebral infarction.