论文部分内容阅读
目的检测非小细胞肺癌组织中IL-6、IL-8、TGF-β的表达情况,探讨其与非小细胞肺癌肺内转移之间的关系,为临床判断预后提供参考。方法选择46例原发性非小细胞肺癌患者手术切除的肺癌组织标本制备组织匀浆,对其组织上清液用ELISA测定IL-6、IL-8、TGF-β的表达情况。结果(1)IL-6、IL-8、TGF-β在46例非小细胞肺癌组织中均有不同程度的表达,其中间值分别为198.127pg/mg、160.988pg/mg、65.433pg/mg。(2)IL-8、TGF-β的表达与非小细胞肺癌肺内转移有关(P=0.047,P=0.001)。结论(1)IL-6、IL-8、TGF-β的表达与非小细胞肺癌组织的生长有关。(2)IL-8、TGF-β参与了非小细胞肺癌肺内转移的过程。
Objective To detect the expression of IL-6, IL-8 and TGF-β in non-small cell lung cancer (NSCLC) and to explore the relationship between IL-6, IL-8 and TGF-β in lung metastasis of non-small cell lung cancer. Methods Tissue homogenates of lung cancer tissues from 46 patients with primary non-small cell lung cancer (NSCLC) were selected and their supernatants were assayed for the expression of IL-6, IL-8 and TGF-β by ELISA. Results (1) The expression of IL-6, IL-8 and TGF-β in 46 cases of non-small cell lung cancer tissues were different, the median values were 198.127pg / mg, 160.988pg / mg and 65.433pg / mg . (2) The expression of IL-8 and TGF-β was related to lung metastasis of non-small cell lung cancer (P = 0.047, P = 0.001). Conclusion (1) The expression of IL-6, IL-8 and TGF-β are related to the growth of non-small cell lung cancer. (2) IL-8 and TGF-β are involved in lung metastasis of non-small cell lung cancer.