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报道包甲素全身及局部用药毒性研究。包甲素苯甲酸盐小鼠腹腔给药的急性LD_(50)为8.85±1.2mg/kg。中毒症状系强烈的拟胆碱作用所致。急性中毒组织病理检查小鼠及猴大致相同,主要是内脏器官淤血。亚急性给药试验提示有一定的积蓄性。慢性滴眼试验,兔内眼及外眼部未见任何明显损害。正常志愿者滴眼试验和匹罗卡品类似,虽有短暂球结膜血管扩张。但毫无不适感觉。解毒试验证明抗胆碱药阿托品是一个高度特异性解毒剂,为临床用药提供了安全保证。
Report the systemic and topical toxicity of The acute LD 50 of intraperitoneal administration of paclitaxel benzoate mice was 8.85 ± 1.2 mg / kg. Symptoms of poisoning due to the strong role of choline. Acute poisoning histopathology mice and monkeys are roughly the same, mainly visceral organ congestion. Subacute drug administration suggests some savings. Chronic eye drops test, rabbit eyes and outside the eye without any significant damage. Drops of eye drops in normal volunteers are similar to those of pilocarpine, although there is brief bulbar conjunctival vasodilation. But no discomfort. Detoxification tests show that anticholinergic atropine is a highly specific antidote for clinical use to provide a safety guarantee.