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Purpose:To observe the clinical efficacy of Compound Hypoglycemic Decoction(CHD)and its effecton serum total cholesterol in model mice.Method:The paired t test was used to analyze the datarecorded before and after administration of drugs for hyperglycemia induced by intraperitonealinjection of 75% egg yolk emulsion in experimental mice.CHD and Fenofibrate were administeredas prevention measures.Results:The total effective rate of serum total cholesterol(TC)decrease in60 cases of hyperglycemia was 86.66% and that of serum total triglyceride(TG)decrease was81.81%.The total effective rate of high-density lipoprotein-cholesterol(HDL-C)increase was 75%.The decrease in TC and TG,and the increase of HDL-C after treatment by in-group comparisonwere all significant(P<0.05).21.9% and 22.2% decrease in the total cholesterol was respectivelyfound in the CHD and Fenofibrate groups(both P<0.05),with no significant difference.Conclusion:The hypoglycemic action of Compound Hypoglycemic Decoction was remarkable in clinical practice,and it is very effective in preventing hyperglycemia in experimental mice.
Purpose:To observe the clinical efficacy of Compound Hypoglycemic Decoction(CHD)and its effecton serum total cholesterol in model mice.Method:The paired t test was used to analyze the datarecorded before and after administration of drugs for hyperglycemia induced by intraperitonealinjection of 75% Egg yolk emulsion in experimental mice.CHD and Fenofibrate were administered as prevention measures.Results:The total effective rate of serum total cholesterol(TC)decrease in60 cases of hyperglycemia was 86.66% and that of serum total triglyceride(TG)decrease was 81.81% .The total effective rate of high-density lipoprotein-cholesterol(HDL-C)increase was 75%.The decrease in TC and TG,and the increase of HDL-C after treatment by in-group comparisonwere all significant (P<0.05) .21.9% and 22.2% decrease in the total cholesterol was respectively found in the CHD and Fenofibrate groups (both P<0.05), with no significant difference.Conclusion:The hypoglycemic action of Compound Hypoglycemic Decoction was r Emarkable in clinical practice, and it is very effective in preventing hyperglycemia in experimental mice.