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阴茎海绵体血管的张力受血管收缩和舒张因子的调控。通常认为NO舒张阴茎小动脉和海绵体平滑肌在阴茎勃起中具有重要作用。最近研究发现,RhoA/Rho激酶参与收缩因子去甲肾上腺素(NE)和内皮素1(ET-1)介导的阴茎小动脉和海绵体平滑肌收缩过程,与NO介导的海绵体平滑肌舒张过程有相互作用,NO的勃起效应可能与阻断RhoA/Rho激酶介导的阴茎海绵体血管平滑肌收缩有关。RhoA/Rho激酶抑制剂在ED的治疗中有广阔的应用前景。
The tension of the cavernous blood vessels is regulated by vasoconstriction and relaxation factors. It is generally believed that NO diastolic penis arterioles and cavernous smooth muscle plays an important role in penile erection. Recent studies have found that RhoA / Rho kinase is involved in the contractile factor norepinephrine (NE) and endothelin-1 (ET-1) -mediated contraction of smooth muscle in the penile arterioles and cavernous muscles and is associated with NO-mediated relaxation of the cavernosal smooth muscle Interaction, NO erection may be related to the inhibition of RhoA / Rho kinase mediated cavernosal smooth muscle contraction. RhoA / Rho kinase inhibitors have broad application prospects in the treatment of ED.