目的 :观察实验狗经内窥镜CO2 激光喉部分切除术后的结构及功能恢复情况、愈合过程及其病理变化。方法 :将 10只狗随机分为 4组 ,在全麻下经喉镜行CO2 激光喉部分切除术 ,术后观察狗喉三大功能的恢复情况 ,并分别于术后 1、2、3、4周将狗处死 ,对喉内情况进行肉眼、光镜及透射电镜观察。结果 :术后实验狗呼吸通畅 ,吞咽良好 ,1～ 2周即能恢复犬吠。病理检查显示其创面及周围组织首先呈现无菌性炎症反应 ,1周左右即可观察到新生上皮及其他组织修复的征像 ,2周时见到以纤维母细胞和新生血管为特征的肉芽组织。 3周时创面已被表面覆盖上皮组织的肉芽完全修复 ,但其微观结构尚未完全恢复正常。 4周时无论其大体或镜下结构均已趋于稳定。结论 :经内窥镜CO2 激光狗喉部分切除术的病理过程与常规手术近似 ,由于不必做气管切开和颈部切口 ,故创伤小、痛苦少、恢复快 ,喉的三大功能恢复良好 ,是进行声带、室带、杓状软骨切除等喉部分切除术的有效方法 Objective: To observe the structure, function recovery, healing process and pathological changes of experimental dogs after endoscopic CO2 laser partial laryngectomy. Methods: Ten dogs were randomly divided into four groups. The patients underwent partial laryngoscopy and CO2 laryngectomy under general anesthesia. After the operation, the recovery of three major functions of dog’s throat was observed. After the operation, The dogs were sacrificed in 4 weeks, and the conditions in the throat were observed by naked eyes, light and transmission electron microscopy. Results: The postoperative dog breathing smoothly, swallowing well, 1 to 2 weeks to restore the bark. Pathological examination showed that the wounds and surrounding tissues first showed aseptic inflammation, signs of repair of epithelial and other tissues were observed in about 1 week, and granulation tissues characterized by fibroblasts and neovascularization were seen in 2 weeks . At 3 weeks, wounds were completely repaired by granulation on epithelial surface covered epithelium, but their microstructure had not returned to normal completely. At 4 weeks either its gross or microscopic structures tended to stabilize. Conclusion: The pathological process of partial laryngectomy with endoscopic CO2 laser in dogs is similar to that of conventional surgery. Because tracheostomy and neck incision are not necessary, it is less traumatic, less painful and faster to recover. The laryngeal three functions recover well, Is an effective method of vocal cord, ventricular band, arytenoidectomy and other partial throat resection