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Caspase-1具有促动脉粥样硬化的作用已经广为人知,但其是否帮助了血管内皮细胞(ECs)感知早期高脂血症并激活ECs还尚不清楚。最近的研究发现,脂肪组织代谢应激时,caspase-1特异剪切组蛋白去乙酰化酶Sirt1。本文研究人员利用(Apo E-/-/caspase-1-/-)双敲小鼠模型,证明了ECs通过caspase-1-sirtuin 1-activator protein-1(AP-1)通路感知早期高脂血症,导致内皮激活,招募单核细胞,动脉粥样硬化生成。
The role of Caspase-1 in promoting atherosclerosis has been well known, but it remains unclear whether it helps endothelial cells (ECs) sense early hyperlipidemia and activate ECs. Recent studies have found that, when adipose tissue is metabolized by stress, caspase-1 specifically cleaves histone deacetylase Sirt1. In this study, we demonstrated that ECs are associated with early hyperlipidemia through the caspase-1-sirtuin 1-activator protein-1 (AP-1) pathway, using a double-knockout mouse model of Apo E - / - / caspase- 1 - / - Disorders, leading to endothelial activation, recruitment of monocytes, and atherosclerosis.