caspase相关论文
细胞焦亡作为炎性反应性的调控性细胞死亡，在生物体抵御外来病原体及各种临床疾病中发挥着重要作用，近年来焦亡通过Caspase激活的具......
背景:尽管通过人乳头瘤病毒（human papilloma virus,HPV）疫苗接种和筛查几乎可以完全预防宫颈癌,但宫颈癌仍是世界范围内影响妇女健......
本课题以山苍子精油为研究对象,分析三种典型产地山苍子精油的化学成分,通过体外培养口腔癌KB细胞实验,观察山苍子精油及其主要成......
癌症是一种常见的死亡概率特别高的重大疾病,已成为人类的第一杀手。多年来,抗肿瘤药物的研究与开发一直医药领域的热点,其中寻找......
目的 研究糖原合成酶激酶-3β(GSK-3β)抑制剂TWS119对多发性骨髓瘤(MM)细胞凋亡和增殖的影响.方法 使用TWS119处理MM细胞系LP1和M......
目的:研究MTFR2在肝细胞癌（hepatocellular carcinoma HCC）中的临床意义及分子机制。方法:（1）通过The Cancer Genome Atlas（TCGA）数据库......
目的:本论文研究人类新基因LACE1的特征及功能,对该基因进行克隆、表达和功能分析,本研究既具有重要的理论意义又具有潜在的应用价......
目的:构建慢性不可预知应激（CUMS）抑郁小鼠模型,对其进行为期8周的跑台运动或游泳运动干预后,观察运动对抑郁小鼠海马神经细胞凋亡因......
在乳恒牙替换过程中,乳牙牙髓组织逐渐减少,这与牙髓组织发生细胞凋亡有关.天冬氨酸特异性蛋白水解酶(cys-teine-containing aspar......
目的 探讨血清半胱氨酸蛋白酶(caspase)及红细胞分布宽度(RDW)水平与一氧化碳中毒迟发性脑病患者病情严重程度的相关性.方法 选取2......
细胞焦亡是新发现的一种程序性促炎症细胞死亡方式,其主要信号通路包括依赖NLRP3炎症小体等激活Caspase-1的经典细胞焦亡通路和依......
目的:明确山柰酚在非小细胞肺癌（NSCLC）中的具体生物学作用,并阐释其具体作用机制。方法:以人NSCLC细胞株H1299和A549为研究对象,MTT......
细胞凋亡是一种发生在多细胞生物体中受到严格控制的程序性细胞死亡,负责消除不需要的细胞,在个体发育与衰老及防御病原体中发挥重......
研究背景:紫外辐射（Ultraviolet radiation,UV）介导的细胞凋亡至少通过2条独立的途径,即DNA损伤和细胞膜死亡受体激活。DNA损伤激活......
目的:分析天花粉蛋白(TCS)、TCS和siPD-1联合用药对卵巢癌细胞凋亡的影响,并探讨其作用机制.方法:将卵巢癌SKOV3细胞接种于6孔板(1......
Pyroptosis is the process of inflammatory cell death.The primary function of pyroptosis is to induce strong inflammatory......
Cloning of the Cell Death Protease Caspase gene from the Oriental Fruit Fly, Bactrocera dorsalis (He
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鸡传染性支气管炎是危害养禽业并造成巨大经济损失的重要传染病之一。鸡传染性支气管炎病毒(Infectious Bronchitis Virus,IBV)与......
A Caspase-Dependent Pathway Is Involved in Wnt/β-Catenin Signaling Promoted Apoptosis in Bacillus Ca
Apoptosis of alveolar macrophages following Mycobacterium tuberculosis infection have been demonstrated to play a centra......
本论文选择在我国分离得到的一株能典型产生麻痹性贝毒(PSP,Paralytic Shellfish Poison)的有毒赤潮甲藻塔玛亚历山大藻(Alexandri......
Object:To detect the expression of TIPE2 in the splenocyte of mouse models with RA induced by cattle collagen Ⅱ and in ......
目的：前期研究中我们已发现Oleandrin对骨肉瘤细胞发挥抗肿瘤活性,但Oleandrin诱导骨肉瘤细胞凋亡的具体机制仍不明确,尚需进一步探......
Picosecond pulsed electric fields induce apoptosis in HeLa cells via the endoplasmic reticulum stres
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Objective To investigate the expression and role of RPS15A in human breast cancer.In this study,we first evaluated the e......
The Mitochondrial Pathway Involved in Rabbit Annulus Fibrosus Cell Apoptosis Induced by Mechanical O
In order to investigate the dominant apoptotic pathway of rabbit annulus fibrosus (AF) cells induced by mechanical over-......
目的 目前，鼻咽癌的主要的治疗手段是放疗为主结合化疗的综合治疗。但放化疗的毒副作用较大，甚至影响治疗进程。因此，寻找新的抗肿瘤......
Constitutive activation of the transcription factor nuclear factor-kB (NF-κB) plays an important role in oncogenesis an......
Acute leukemia is a malignant clonal hematopoietic stem cell disease.It occurs in all age groups,and has the highest mor......
Sodium fluoride induces apoptosis in the kidneys of rats through caspase-mediated pathways and DNA d
Objective Long-term excessive sodium fluoride (NaF) intake can cause many bone diseases and non-skeletal fluorosis.The k......
Sodium fluoride induces apoptosis in the kidneys of rats through caspase-mediated pathways and DNA d
Objective Long-term excessive sodium fluoride (NaF) intake can cause many bone diseases and non-skeletal fluorosis.The k......
本实验研究了本实验从猪软骨中提取一种软骨多糖并探讨其对人慢性髓系白血病K562细胞的抑制机制.研究表明:软骨多糖可以抑制K562细......
镉是一种致癌、致畸、致突变的有毒重金属,水生生物主要通过呼吸、消化和皮肤吸收等途径积累在体中.本实验选用河南华溪蟹(Sinopot......
Purpose Retinal ischemia/reperfusion(I/R)injury has been implicated in many ocular diseases,because it leads to retinal ......
目的 探讨紫铆因对儿童急性淋巴细胞白血病(ALL)细胞增殖及细胞凋亡的作用及其机制。方法 采用Ficoll-Paque 分离液分离16例初发患......
Background:Apoptosis is a programmed cell death with distinct biochemical and genetic features essential for development......
Antiproliferation activity of Triterpenoid Saponins AG4 from Ardisia Gigantifolia Stapf on MCF-7 cel
Aim: AG4 is a anti-tumor compound derived from Ardisia gigantifolia Stapf.The aim of this study was to investigate the i......
目的 探讨丹皮酚对体外培养人黑素瘤A375细胞增殖和凋亡的影响及其作用机制.方法 利用CCK8检测不同浓度和时间丹皮酚作用下对黑素......
Down-regulation of Poly (ADP-ribose) polymerase 1 Leads to Change of Hydroquinone Cytotoxicity in TK
Hydroquinone (HQ), a metabolite of benzene, is known to be associated with acute myelogenous leukemia (AML) risk;however......
Soluble amyloid β-enhanced LTD in rat dentate gyrus of hippocampus is mGluR1/5-dependent and involve
Accumulation of amyloid beta (Aβ) protein is a key pathogenic element of Alzheimers disease.It is reported that the Aβ......
核凋亡诱导因子1 (Nuclear Apoptosis-Inducing Factor 1,NAIF1)自发现以来于肿瘤组织中的表达及相关功能还尚不明确.本实验室通过......
细胞焦亡是除了细胞凋亡、细胞坏死之外的另一种细胞死亡方式,目前研究表明发生细胞焦亡时,gasdeimin蛋白家族的GSDMD被caspase蛋......
方法：在体实验中,于新生鼠第出生后2天时给予母鼠n-3 PUFA饮食干预,使用出生后第7天的新生鼠制备H/I疾病模型,检测术后0-24小时神经......
Targeting prodeath signaling upstream of mitochondria damage-cathepsins in astrocytes contributes to
The roles of cathepsins in the ischemic astrocytic injury remain unclear.Here we test the hypothesis that the activation......
