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目的研究远程氩等离子体对医用聚四氟乙烯(PTFE)表面的灭菌及改性。方法通过载体定量灭菌实验测定远程氩等离子体对PTFE表面大肠杆菌的杀灭效果,并利用接触角测量、质量损失率计算和X射线光电子能谱分析(XPS)研究灭菌前后PTFE表面结构、性能的变化。结果在放电功率100 W,放电时间120 s,氩气流量20 cm3/min的条件下,远程及常规氩等离子体均可有效灭活大肠杆菌(GE≥3.769);但经远程氩等离子体灭菌后,PTFE表面的亲水性(水接触角为58.5°)明显优于常规氩等离子体灭菌后的PTFE表面(水接触角为70.5°),同时受损及降解程度低(表面质量损失率仅为11.8%)。远程氩等离子体可以在一定程度上抑制电子、离子的刻蚀作用,强化自由基反应,对PTFE表面的脱氟作用更强,从而引入更多的含氧基团。结论远程氩等离子体在有效杀灭大肠杆菌的同时,可使PTFE表面获得更好的改性效果。
Objective To study the sterilization and modification of medical polytetrafluoroethylene (PTFE) surface by remote argon plasma. Methods The killing effect of remote argon plasma on the surface of PTFE was measured by the vector quantitative sterilization experiment. The surface structure of the PTFE before and after sterilization was investigated by the contact angle measurement, mass loss rate calculation and X-ray photoelectron spectroscopy (XPS) Performance changes. Results Both the remote and conventional argon plasma could effectively inactivate Escherichia coli (GE≥3.769) under the conditions of discharge power of 100 W, discharge time of 120 s and argon flow rate of 20 cm3 / min. However, the bacteria were sterilized by remote argon plasma , The hydrophilicity of the PTFE surface (water contact angle of 58.5 °) was significantly better than that of the conventional argon plasma-sterilized PTFE surface (water contact angle of 70.5 °) with low damage and degradation (surface mass loss rate Only 11.8%). Remote argon plasma can inhibit the electron and ion etching to a certain extent, strengthen the free radical reaction, and de-fluorine effect on the PTFE surface stronger, so as to introduce more oxygen-containing groups. Conclusion Long-distance argon plasma can effectively kill E. coli, PTFE surface can get better modification.