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13例成年草原黄鼠通过不同途径注射0.2ml HBcAg阳性人血清.另有4只不经任何注射的黄鼠用作对照,经6、7、8wk后采集血清及肝组织标本.应用核酸杂交Spot法和SPRIA法检测血清标本,有12例感染黄鼠Spot法为阳性结果,SPRIA法仅1例为阳性.12例感染组黄鼠肝活检的组织切片光镜观察,有类似人的急性传染性肝炎的组织学改变.对照组黄鼠血清及肝脏组织学改变全部正常.以上结果表明草原黄鼠可由HBV感染引起急性肝炎,因此它可作为研究人的急性病毒性肝炎病因,发病机理的很好的动物模型.
Thirteen adult chrysalis were injected with 0.2ml HBcAg-positive human serum by different routes, and another 4 chrysomilates without any injection were used as controls, and serum and liver tissue samples were collected after 6, 7 and 8 weeks.Using nucleic acid hybridization Spot Serum samples were detected by SPRIA and SPRIA method, and 12 cases were infected with spotted Spotchia chinensis, and only one case was positive with SPRIA method. The histological sections of 12 cases of infected chondritic liver biopsy were observed by light microscopy, with similar human acute infectious Hepatitis histological changes in the control group, serum and liver histological changes were normal.Above all, the above results show that prairie rats caused by HBV infection of acute hepatitis, so it can be used as a study of human etiology of acute viral hepatitis, the pathogenesis is very good Animal model.