论文部分内容阅读
目的探讨胰岛素泵强化治疗初诊2型糖尿病患者在改善患者的胰岛素抵抗和胰岛素分泌中的作用。方法40例病程≤1年、未用过任何降糖药的2型糖尿病患者进行胰岛素泵强化治疗,以空腹血糖≤6.0 mmol/L、餐后2小时血糖≤8.0 mmol/L为血糖控制目标,使血糖在7~10 d达标,并维持2周以上,比较治疗前后的静脉葡萄糖耐量试验、胰岛素第一时相分泌,胰岛素抵抗指数(Hom aA),胰岛素分泌指数(Hom aB)的变化。结果胰岛素泵强化治疗方案可以使短病程的、未用过降糖药的2型糖尿病患者的血糖达标,治疗后静脉葡萄糖耐量试验中空腹胰岛素水平以上的胰岛素曲线下面积、Hom aB均较治疗前明显升高(P<0.05),Hom aA明显下降(P<0.01)。结论胰岛素泵强化治疗方案可能诱导出部分初诊的2型糖尿病患者的蜜月期,使患者的胰岛素抵抗及胰岛素B细胞功能得到不同程度的改善。
Objective To investigate the role of insulin pump in the treatment of newly diagnosed type 2 diabetic patients in improving insulin resistance and insulin secretion. Methods Forty patients with type 1 diabetes without any hypoglycemic agents undergoing intensive insulin therapy were treated with fasting blood glucose ≤6.0 mmol / L and postprandial 2-hour glucose ≤8.0 mmol / L for blood glucose control. The blood glucose level was achieved at 7-10 days and maintained for more than two weeks. The changes of venous glucose tolerance test, first phase insulin secretion, HomAA and HomAB were compared before and after treatment. Results Insulin pump intensive treatment regimen could achieve blood glucose level of type 2 diabetes patients without any hypoglycemic agents in a short course of time. After treatment, the area under the curve of insulin above the fasting insulin level in the intravenous glucose tolerance test, Hom aB, (P <0.05), Hom aA decreased significantly (P <0.01). Conclusions Insulin pump intensive treatment regimen may induce honeymoon in some newly diagnosed type 2 diabetic patients, which may result in the improvement of insulin resistance and insulin B cell function in patients.