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目的探讨类风湿关节炎(RA)与系统性红斑狼疮(SLE)重叠综合征(Rhupus综合征)临床特点。方法对1例Rhupus综合征患者的临床、实验室、影像学资料、治疗及预后进行回顾性分析,结合文献资料复习,探讨Rhupus综合征的临床特点。结果本例患者为中年女性,先出现RA表现,7年后出现SLE表现。本例患者肾脏损害重,有肾功能不全,糖皮质激素联合环磷酰胺治疗有效。结论Rhupus综合征在临床上罕见,患者往往先出现一种疾病的表现,数年至十余年后出现另一种疾病的表现,激素和免疫抑制剂治疗有效,及时诊断及正确治疗对于改善患者预后具有重要意义。
Objective To investigate the clinical features of rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) overlap syndrome (Rhupus syndrome). Methods The clinical, laboratory, imaging data, treatment and prognosis of 1 Rhupus syndrome were retrospectively analyzed. The clinical features of Rhupus syndrome were discussed with reference to literature review. Results The patients were middle-aged women, the first appearance of RA, SLE appeared after 7 years. The patients with kidney damage, renal insufficiency, glucocorticoid treatment combined with cyclophosphamide effective. Conclusions Rhupus syndrome is clinically rare. Patients often show the appearance of a disease first, and the appearance of another disease after a few years to more than ten years. The effective treatment of hormones and immunosuppressive agents, timely diagnosis and correct treatment are of great value in improving patients The prognosis is of great significance.