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目的分析妊娠妇女TORCH感染与妊娠结局相关性。方法检索1991年~2010年间国内发表的关于妊娠妇女TORCH感染与妊娠结局的关系的病例资料,采用Review Manager 4.2软件进行Meta分析。结果共纳入6篇相关文献,TORCH感染2413例,对照5370例。Meta分析结果显示,不良妊娠组弓形虫、风疹病毒、巨细胞病毒、单纯疱疹病毒Ⅱ感染率明显高于正常妊娠组,OR值(95%CI)分别为6.00(3.82~9.42)、9.90(3.61~27.17)、6.70(4.36~10.27)、6.24(2.84~13.73)(P<0.01);漏斗图分析无明显发表偏倚。结论 TORCH感染是我国妊娠妇女不良妊娠结局的重要危险因素,应重视TORCH感染的早期筛查与诊治。
Objective To analyze the correlation between TORCH infection and pregnancy outcome in pregnant women. Methods The data of the cases published between 1991 and 2010 in China on the relationship between TORCH infection and pregnancy outcome were retrieved and Meta-analysis was performed using Review Manager 4.2 software. Results A total of 6 related articles were included. There were 2413 cases of TORCH infection and 5370 cases of control. Meta analysis showed that Toxoplasma gondii, rubella virus, cytomegalovirus and herpes simplex virus Ⅱ infection rates in adverse pregnancy group were significantly higher than those in normal pregnancy group (OR: 95% CI: 6.00, 3.82-9.42, ~ 27.17), 6.70 (4.36 ~ 10.27) and 6.24 (2.84 ~ 13.73) respectively (P <0.01). There was no obvious published bias in funnel analysis. Conclusion TORCH infection is an important risk factor of adverse pregnancy outcome in pregnant women in China. Early screening and diagnosis of TORCH infection should be emphasized.