动脉粥样硬化病变的发生与血管内皮损伤及血管内膜通透性的改变密切有关。以往我们曾用伊文思蓝活体染色法检测血管内膜的通透性变化,但此方法仅限于肉眼对病变观察,并不能作为一种示踪剂进行超微结构方面的研究。硝酸镧曾被用以检测受损心肌和骨骼肌细胞膜通透性改变的标志。本实验利用硝酸镧检测高脂饮食和注射肾上腺素后,兔血管内膜在超微结构上所显示的通透性改变。 The occurrence of atherosclerotic lesions is closely related to the changes of vascular endothelial injury and vascular intimal permeability. In the past, Evans blue staining was used to detect changes in the intima of the blood vessels. However, this method is limited to macroscopic observation of lesions and can not be used as a tracer for ultrastructural studies. Lanthanum nitrate has been used to detect signs of altered permeability of damaged myocardial and skeletal muscle cell membranes. In this experiment, we detected the ultrastructure changes of rabbit vascular intima after the high-fat diet and the injection of epinephrine by using lanthanum nitrate.