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[目的]探讨高尿酸血症的慢性心衰患者,别嘌呤醇治疗对其心功能的影响。[方法]56例心功能II～III级慢性心衰患者分为别嘌呤醇治疗组和对照组。所有对照组患者均于入院后给予常规抗心衰治疗,治疗组在对照组治疗基础上加用别嘌呤醇300mg/d,治疗12周。分别检测治疗前、后血尿酸、左心室舒张末期内径和左心室射血分数的变化。[结果]与治疗前相比,别嘌呤醇组治疗后左心室舒张末期内径明显降低,左心室射血分数升高(P﹤0.05)。与对照组相比,别嘌呤醇组治疗后左心室舒张末期内径,左心室射血分数的改善更为明显(P﹤0.05)。[结论]别嘌呤醇能降低体内氧化应激水平,改善心功能。
[Objective] To investigate the effect of allopurinol on cardiac function in patients with chronic heart failure with hyperuricemia. [Methods] Fifty-six patients with heart failure grade II-III were divided into allopurinol group and control group. All patients in the control group were given routine anti-heart failure treatment after admission. The treatment group was given allopurinol 300 mg / d on the basis of the control group for 12 weeks. Changes of serum uric acid, left ventricular end-diastolic diameter and left ventricular ejection fraction before and after treatment were measured. [Results] Compared with those before treatment, the mean diastolic diameter of left ventricle in allopurinol group was significantly decreased and the left ventricular ejection fraction increased (P <0.05). Compared with the control group, allopurinol group after treatment, left ventricular end-diastolic diameter, left ventricular ejection fraction improved more significantly (P <0.05). [Conclusion] Allopurinol can reduce the level of oxidative stress in vivo and improve cardiac function.