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目的:研究疏血通注射液与4种溶媒的配伍稳定性方法:以次黄嘌呤为检测指标,采用HPLC法测定疏血通注射液与4种输液在室温下配伍后6 h内不同时间的含量变化,并按《中国药典》2010年版附录对配伍液进行外观性状观察及pH、不溶性微粒数的测定。结果:疏血通注射液配伍液在6 h内无浑浊、沉淀、气体产生,颜色、pH等无明显变化;与5%葡萄糖氯化钠注射液配伍液不溶性微粒数有所升高,与时间有关;与10%葡萄糖注射液配伍液中次黄嘌呤的含量有所下降,与时间有关。结论:6 ml疏血通注射液可分别与250 ml的5%葡萄糖注射液、0.9%氯化钠溶液在常温下配伍,于6 h内使用。
OBJECTIVE: To study the compatibility stability of Shuxuetong injection with four kinds of vehicles: Using hypoxanthine as detection index, the effect of Shuxuetong injection and four kinds of infusion at different time within 6 h after compatibility at room temperature Content changes, and according to “Chinese Pharmacopoeia” 2010 edition appendix on the compatibility of liquid appearance observation and pH, the determination of the number of insoluble particles. Results: There was no obvious change in the compatibility of Shuxuetong injection solution within 6 hours, the precipitation, gas production, color, pH and so on. There was an increase in the number of insoluble particles in the compatibility solution with 5% glucose and sodium chloride injection, Related; and 10% glucose injection compatibility hypoxanthine content decreased, with time. Conclusion: 6 ml Shuxuetong injection with 250 ml of 5% glucose injection, 0.9% sodium chloride solution compatibility at room temperature, within 6 h.