论文部分内容阅读
目的了解云南省德宏州男男性行为HIV感染者抗病毒治疗现状及影响因素。方法收集德宏州《国家艾滋病综合防治信息系统》病例报告库和治疗库中男男性行为HIV感染者相关信息并进行统计学分析。结果截至2016年8月,德宏州新报告男男性行为HIV感染者90例,其中中国籍71例(78.9%),外国籍19例(21.1%);68例(75.6%)已接受抗病毒治疗,中国籍病例接受抗病毒治疗的比例为83.1%,外国籍为47.4%;病例从发现到启动抗病毒治疗的时间中位数为19.5 d(IQR:7.0~66.5 d)。影响该类人群抗病毒治疗接受率的因素包括国籍(OR_(外籍vs中国籍)=0.28,95%CI:0.09~0.93)、民族(OR_(少数民族vs汉族)=0.31,95%CI:0.10~0.97)。51例目前在治且定期随访者的基线CD4细胞计数为(383.43±226.41)个/μL,最近一次随访CD4细胞计数为(665.63±364.10)个/μL,平均增长(282.20±276.02)个/μL;其中42例(82.4%)进行了HIV病毒载量检测,病毒完全抑制者占92.9%(39/42),病毒抑制不确定者占7.1%(3/42),无病毒抑制失败者。结论德宏州男男性行为HIV感染者抗病毒治疗比例较高,治疗效果较好,但仍需加强外国籍、少数民族男男性行为HIV感染者的抗病毒治疗覆盖率。
Objective To understand the current situation and influencing factors of antiviral therapy in HIV-positive men who have sex with men in Dehong Prefecture of Yunnan Province. Methods The relevant information of HIV-infected men who have sex with men (MSM) in the case report database of “National AIDS Integrated Prevention and Control Information System” in Dehong Prefecture was collected and statistically analyzed. Results As of August 2016, there were 90 new cases of HIV-positive men who reported MSM in Dehong Prefecture, of which 71 (78.9%) were Chinese, 19 (21.1%) were foreign, and 68 (75.6%) were HIV- In treatment, the proportion of Chinese patients receiving antiretroviral therapy was 83.1% and that of foreign nationals was 47.4%. The median time from discovery to initiation of antiretroviral treatment was 19.5 days (IQR: 7.0-66.5 days). The factors influencing the acceptance rate of anti-viral treatment in this population include nationality (OR_ (foreign vs Chinese) = 0.28, 95% CI: 0.09-0.93), ethnicity (OR_ (minority vs Han) = 0.31, 95% CI: 0.10 ~ 0.97). The baseline CD4 cell count was 383.43 ± 226.41 / μL in the 51 patients who underwent regular follow-up and the last follow-up CD4 cell count was (665.63 ± 364.10) / μL with an average increase of (282.20 ± 276.02) cells / μL Among them, 42 cases (82.4%) were tested for HIV viral load, which accounted for 92.9% (39/42) of patients with complete virus suppression and 7.1% (3/42) of patients with unknown virus suppression without any virus failure. Conclusions There is a high proportion of anti-virus treatment in HIV-positive men who have sex with men and women in Dehong prefecture, and the treatment effect is better. However, coverage of anti-virus treatment of HIV-infected men and women of ethnic minorities in China and ethnic minorities still needs to be strengthened.