论文部分内容阅读
目的系统评价早期乳腺癌保乳术后单导管球囊近距离加速部分乳腺放疗的美容效果及不良反应。方法计算机检索EMbase、MEDLINE、CNKI、CBM和Wan Fang Data,收集所有球囊治疗早期乳腺癌的临床研究,检索时间从建库截至2016年3月。采用AHRQ量表评价纳入横断面研究的偏倚风险,采用Open Meta、Stata软件进行Meta分析。结果共纳入20个病例系列研究,共3 796例患者。单组率的Meta分析结果显示:美容效果良好率为93%[95%CI(0.91,0.96)],5年同侧乳房内复发率为3%[95%CI(0.020,0.040)]。结论早期乳腺癌保乳术后单导管球囊近距离加速部分乳腺放疗的美容效果较好,局部复发率更低。受纳入研究数量和质量所限,上述结论可能存在偏倚,需开展前瞻性随机对照试验予以验证。
OBJECTIVE: To evaluate the cosmetic effect and side effects of partial mammary radiotherapy in the early stage of breast cancer after breast-conserving surgery. Methods The computerized clinical studies of EMbase, MEDLINE, CNKI, CBM and Wan Fang Data were performed to collect all the balloons for the treatment of early stage breast cancer. The retrieval time was from March to March 2016. The risk of bias included in the cross-sectional study was evaluated using the AHRQ scale and Meta-analysis was performed using Open Meta and Stata software. Results A total of 20 case series studies were included, with a total of 3 796 patients. A single-rate meta-analysis showed a good cosmetic outcome of 93% [95% CI (0.91, 0.96)] and a 5% ipsilateral recurrence rate of 3% (95% CI 0.020,0.040). Conclusion The early breast cancer after breast-conserving catheter proximal balloon accelerated partial breast radiotherapy cosmetic effect is better, the local recurrence rate is lower. Subject to inclusion of the quantity and quality of the study, these conclusions may be biased and need to be prospectively randomized controlled trials to be validated.