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目的:探讨在常规治疗基础上行早期连续性血液净化(CBP)治疗重症急性胰腺炎(SAP)的临床疗效。方法:将我科2011年5月至2013年4月收治的SAP患者36例随机分为对照组和治疗组各18例。对照组予常规治疗,治疗组在常规治疗基础上行早期CBP治疗,比较两组患者病死率及治疗前后1 d、3 d、5 d APACHEⅡ评分、血浆TNF-α和IL-8水平的变化。结果:治疗组的病死率5.6%小于对照组的22.2%,但差异元统计学意义(P>0.05);治疗组治疗后1 d、3 d、5 d APACHEⅡ评分、血浆TNF-α和IL-8水平较对照组均明显下降(P<0.05)。结论:在常规治疗基础上实施早期CBP治疗可改善SAP的临床症状,保护器官功能,改善预后。
Objective: To investigate the clinical efficacy of early continuous blood purification (CBP) in the treatment of severe acute pancreatitis (SAP) on the basis of routine treatment. Methods: 36 cases of SAP patients who were treated in our department from May 2011 to April 2013 were randomly divided into control group and treatment group, 18 cases each. The control group was given routine treatment. The treatment group received early CBP on the basis of conventional treatment. The mortality and the APACHEⅡscore, plasma TNF-α and IL-8 levels at 1, 3 and 5 days after treatment were compared between the two groups. Results: The mortality of treatment group was 5.6% less than that of control group (22.2%), but the difference was statistically significant (P> 0.05). The APACHEⅡscore, plasma TNF-α and IL- 8 levels were significantly lower than the control group (P <0.05). Conclusion: The implementation of CBP on the basis of conventional treatment can improve the clinical symptoms of SAP, protect organ function and improve prognosis.