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目的:探讨前列地尔联合硫辛酸治疗糖尿病足的临床效果和安全性。方法:将2009年1月至2012年12月收治的糖尿病足患者101例随机分为对照组(n=49)和治疗组(n=52),对照组予以严格控制血糖、血压、清创、改善循环、抗感染等常规治疗,治疗组在对照组治疗的基础上加用前列地尔10 ug加入生理盐水100 ml中静脉滴注,每日一次,硫辛酸300 mg加入生理盐水250 ml中静脉滴注,每日一次,2周为一疗程,比较2疗程后两组的临床疗效和不良反应。结果:治疗组总有效率92.3%(48/52)明显高于对照组的67.4%(33/49),P<0.01;两组均未发现明显毒副作用。结论:在常规治疗的基础上,加用前列地尔和硫辛酸治疗糖尿病足能提高疗效,且无明显副作用。
Objective: To investigate the clinical efficacy and safety of alprostadil combined with lipoic acid in the treatment of diabetic foot. Methods: 101 patients with diabetic foot admitted from January 2009 to December 2012 were randomly divided into control group (n = 49) and treatment group (n = 52). The control group was given strict control of blood glucose, blood pressure, debridement, Improve the circulation, anti-infection and other conventional treatment, the treatment group in the control group based on the treatment plus alprostadil 10 ug saline 100 ml infusion, once daily, lipoic acid 300 mg added 250 ml of normal saline vein Instillation, once a day, 2 weeks for a course of treatment, the two groups were compared after 2 courses of clinical efficacy and adverse reactions. Results: The total effective rate was 92.3% (48/52) in the treatment group, which was significantly higher than that in the control group (67.4%, 33/49), P <0.01. No obvious side effects were found in both groups. Conclusion: On the basis of routine treatment, the treatment of diabetic foot with alprostadil and lipoic acid can improve the curative effect without obvious side effects.