ＩＬ－６的多种生物效应都是通过靶细胞膜上的ＩＬ－６受体来介导的。临床上的多种疾病不仅与ＩＬ－６分泌异常有关，而且也与ＩＬ－６受体的异常表达有关。ＩＬ－６／ＩＬ－６Ｒ形成的自泌作用机制对于多发性骨髓瘤细胞的产生和增殖起着主要的作用，而对于急、慢性白血病细胞则表现出明显的抗增殖、促分化的作用。随着可溶性ＩＬ－６以及ＩＬ－６Ｒ阻断剂研究的不断深入，对于探讨某些疾病的发病机理和寻找新的治疗途径将是十分有意义的。 Many of the biological effects of IL-6 are mediated by IL-6 receptors on the target cell membrane. Many clinical diseases are not only related to the abnormal secretion of IL-6, but also to the abnormal expression of IL-6 receptor. The autocrine mechanism of IL-6 / IL-6R plays a major role in the generation and proliferation of multiple myeloma cells, while it shows obvious antiproliferative and differentiation effects in acute and chronic leukemia cells. With the continuous research of soluble IL-6 and IL-6R blockers, it will be very meaningful to explore the pathogenesis of certain diseases and find new therapeutic approaches.