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目的观察知柏合剂治疗女童特发性中枢性性早熟的临床疗效。方法选取2013年1月-2014年12月武汉市妇女儿童医疗保健中心43例患儿为研究对象,选用知柏合剂(知母、黄柏、夏枯草、白芍、生地、丹皮)随症加减治疗,3个月为1疗程,2个疗程后观察患儿第二性征、血清性激素水平、妇科彩超,骨骼生长改善情况。结果治疗后第二性征、血清性激素水平、妇科彩超及骨骼生长均明显改善,与治疗前比较差异均有统计学意义(P<0.05)。结论知柏合剂治疗女童特发性性早熟疗效肯定。
Objective To observe the clinical efficacy of Zhibai mixture in treating idiopathic central precocious puberty in girls. Methods A total of 43 children from Wuhan Women and Children Health Care Center from January 2013 to December 2014 were enrolled in this study. Less treatment, 3 months for a course of treatment, 2 after treatment of children with secondary sexual characteristics, serum sex hormone levels, gynecological ultrasound, bone growth and improvement. Results After treatment, the second sexual characteristics, serum sex hormone levels, gynecological color Doppler ultrasound and bone growth were significantly improved, with statistical significance (P <0.05). Conclusions Zhibai mixture is effective in treating idiopathic precocious puberty in girls.