论文部分内容阅读
以履代(口片)吶酮,经1,2,4-三唑取以、溴以、硫脲环合得到4-叔丁基-5-(1,2,4-三唑-1-基)-2-氨基噻唑;再与芳醛缩合合成一系列新4-叔丁基-5-(1,2,4-三唑-1-基)-2-苄亚氨基噻唑(5).用单晶X射线衍射测定了化合物5a的晶体结构.化合物5a的晶体属三斜晶系,空间群以P-1,晶胞参数以:a=0.72749(12)nm,b=0.93463(15)nm,c=1.3398(2)nm,α=70.185(2)°,β=75.669(2)°,γ=73.611(2)°;V=0.8105(2)nm3,Z=2,Dc=1.342g/cm3,F(000)=344,R1=0.0431,wR2=0.1611,S=1.01.生物活性实验结果表明:化合物5c(25mg/L)对小麦赤霉病菌、稻曲病菌、对黄瓜灰霉病菌和稻纹枯病菌的抑制率分别以100%,100%,82.8%和80.3%.化合物5d(25mg/L)对稻纹枯病菌、油菜菌核病菌、小麦赤霉病菌和稻曲病菌的抑制率分别以100%,95.5%,100%和100%.化合物5e(25mg/L)对小麦赤霉病菌的抑制率以100%.5d对小麦赤霉病菌、油菜菌核病菌和水稻纹枯病菌的EC50值分别以1.16,1.38和1.47mg/L.
In order to fulfill the (oral) ketone, obtained by 1,2,4-triazole, bromine and thiourea were cyclized to give 4-tert-butyl-5- (1,2,4-triazol- Yl) -2-aminothiazole. A series of new 4-tert-butyl-5- (1,2,4-triazol-1-yl) -2-benzyliminothiazole (5) were synthesized by condensation with aryl aldehydes. The crystal structure of compound 5a was determined by single crystal X-ray diffraction. The crystal of compound 5a belongs to the triclinic system with P-1 space group and the unit cell parameters are a = 0.72749 (12) nm, b = 0.93463 α = 70.185 (2) °, β = 75.669 (2) °, γ = 73.611 (2) °; V = 0.8105 (2) nm3, Z = 2, Dc = 1.342 g /cm3,F(000)=344,R1=0.0431,wR2=0.1611,S=1.01. The results of biological activity showed that the inhibitory effect of compound 5c (25mg / L) on Fusarium graminearum, And Rhizoctonia solani were 100%, 100%, 82.8% and 80.3%, respectively.Compound 5d (25mg / L) was effective against Rhizoctonia solani, Sclerotinia sclerotiorum, Were 100%, 95.5%, 100% and 100%, respectively.The inhibitory rate of compound 5e (25mg / L) against Fusarium graminearum was 100% The EC50 values of the pathogenic bacteria were 1.16, 1.38 and 1.47 mg / L, respectively.