The Yangtze Delta is one of the economically most developed areas in China. It is located in the eastern China monsoon region. Archaeological excavations and environment-archaeology studies over many years in this region provide exceptional information about climate changes, development of human civilization and also human-environment interactions. Archaeological excavations made in the study region reveal that the development of Neolithic cultures is not continuous, which may be a result of extreme climatic events. The analysis of 14C-dated buried paleotrees, peat and shell ridges show the rise and fall of human civilization in the study area. The research results presented in this paper confirm that human civilization collapsed six times in the Yangtze Delta, matching six high sea level epoches, peat accumulation and buried paleotrees formation periods respectively. This indicates that human activities in the Yangtze Delta are controlled by local climate changes and changing hydrological conditions. The collapse of the Liangzhu culture (5000 aBP-3800 aBP) in about 4000 aBP, after a tremendous flooding event, followed by a relatively backward Maqiao culture (3800 aBP-3200 aBP) confused researchers and aroused their great interest. The research results in this paper show that the collapse of the Liangzhu culture is a result of several factors, for example war and food shortage, but the flooding event occurred in the late Liangzhu culture epoch is the main factor therein.