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目的 Epstein—Barr病毒(EBV)感染是鼻咽癌(NPC)的病因之一,为验证EBV—DNA检测用于北方低发区NPC辅助诊断的特异性。方法 我们采用聚合酶链式反应技术(PCR)检测了37例黑龙江省籍NPC病人癌组织标本。结果 A型EBV—DNA阳性率75.68％,其中低分化癌及未分化癌的阳性率分别为83.93％和100％。B型阳性率为8.10％。结论 中国北方低发区NPC EBV感染的优势型为A型EBV,PCR检测EBV—DNA可用于北方低发区病人的辅助诊断。
Objective Epstein-Barr virus (EBV) infection is one of the causes of nasopharyngeal carcinoma (NPC). To verify the specificity of EBV-DNA detection for NPC-assisted diagnosis in the northern part of China. Methods We used polymerase chain reaction (PCR) to detect 37 cases of NPC patients with NPC in Heilongjiang Province. Results The positive rate of type A EBV-DNA was 75.68%. The positive rates of poorly differentiated carcinoma and undifferentiated carcinoma were 83.93% and 100% respectively. The positive rate of B type was 8.10%. Conclusion The predominant type of EBV infection in NPC in northern China with low incidence is EBV-type EBV. PCR-based detection of EBV-DNA can be used to diagnose patients with low EBV in northern China.