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弗来明(Fleming)1928年发现青霉菌的代谢产物青霉素,1942年牛津大学Florey、Chain试验小组将青霉素G应用于临床.从此以后,抗生素作为抗细菌感染症的主要药物使用已经有近半个世纪的历史.直到50年代,除了青霉素G外,链霉素、四环素、氯霉素,大环内酯抗生素等广谱抗生素作为细菌蛋白质合成抑制剂使用,到了60年代,氨苄青霉素作为广谱青霉素及头孢菌素Ⅳ或唑啉头孢菌素等第一代头孢菌素已经得到广泛应用.这些抗生素的发展主要是由于耐药菌的增加,由于某种抗生素使用一定的时间
Fleming discovered penicillin, a metabolite of Penicillium, in 1928 and was used clinically by the Florey, Chain team in Oxford University in 1942. From then on, nearly half of antibiotics have been used as the primary drug for anti-bacterial infections Century history. Until the 1950s, in addition to penicillin G, streptomycin, tetracycline, chloramphenicol, macrolide antibiotics and other broad-spectrum antibiotics as bacterial protein synthesis inhibitors, to the 60’s, ampicillin as a broad-spectrum penicillin And cephalosporins Ⅳ or oxazoline cephalosporins and other first-generation cephalosporins have been widely used.The development of these antibiotics is mainly due to the increase of resistant bacteria, due to the use of certain antibiotics for a certain period of time