论文部分内容阅读
目的探讨B型脑钠尿肽(BNP)在鉴别心源性与肺源性呼吸困难中的临床应用。方法用酶联免疫分析法测定156例急性呼吸困难患者的BNP水平,包括心源性呼吸困难92例,肺源性呼吸困难64例,比较两者之间差异,并比较心源性呼吸困难组不同心功能分级(NYHA)之间BNP水平及左室射血分数(LVEF)的差异。结果心源性呼吸困难组BNP浓度明显高于肺源性呼吸困难组(P<0.01),LVEF明显低于肺源性呼吸困难组(P<0.01);不同心功能分级亚组之间BNP比较差异有统计学意义(P<0.05)。结论 BNP的测定有助于心源性呼吸困难与肺源性困难的鉴别诊断,并可指导心功能分级,进一步指导治疗。
Objective To investigate the clinical application of B-type natriuretic peptide (BNP) in the differential diagnosis of cardiogenic and pulmonary-derived dyspnea. Methods The BNP levels in 156 patients with acute dyspnea were determined by enzyme-linked immunosorbent assay (ELISA), including 92 cases of cardiogenic dyspnea and 64 cases of pulmonary dyspnea. The differences between the two groups were compared, Differences in BNP levels and left ventricular ejection fraction (LVEF) between different cardiac function classes (NYHA). Results BNP levels in patients with cardiogenic dyspnea were significantly higher than those in patients with pulmonary dyspnea (P <0.01), and LVEF was significantly lower than those in patients with pulmonary dyspnea (P <0.01). Comparison of BNP between different cardiac function subgroups The difference was statistically significant (P <0.05). Conclusion The determination of BNP is helpful for the differential diagnosis of cardiogenic dyspnea and pulmonary dysfunction. It can guide the classification of cardiac function and further guide the treatment.