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目的:分析与比较抗菌药物专项整治活动对医院抗菌药物临床使用的合理性。方法:调取医院HIS系统2012年—2015年间抗菌药物使用数据,分析抗菌药物专项整治对各指标的影响。结果:2012年—2015年间医院抗菌药物销售金额占药品销售总金额分别为25.57%,21.86%,20.16%和20.79%,呈逐年下降趋势;DDDs排序前10位的抗菌药物中口服剂型呈逐年增长,且绝大多数限定日费用(DDDc)在100元以下;每年各类抗菌药物销售金额居前3位的是头孢菌素类、青霉素类和氟喹诺酮类;门急诊和住院患者抗菌药物的使用率、使用强度、Ⅰ类切口围术期抗菌药物预防使用率呈逐年下降,而病原学送检率则逐年上升。结论:抗菌药物专项整治活动效果较明显,加强监管力度后,极大地促进了抗菌药物临床的合理使用。
OBJECTIVE: To analyze and compare the rationality of antimicrobial agents for clinical use in hospitals. Methods: The data of antimicrobial use in hospital HIS system from 2012 to 2015 were retrieved to analyze the impact of antimicrobial treatment on each index. Results: The total amount of sales of antimicrobial drugs in hospitals accounted for 25.57%, 21.86%, 20.16% and 20.79% respectively from 2012 to 2015, showing a declining trend year by year. The oral dosage form of the top 10 antimicrobials ranked by DDDs increased year by year , And the vast majority of DDDc below 100 yuan; annual sales of various types of antimicrobial drugs in the top three cephalosporins, penicillins and fluoroquinolones; outpatient and inpatient use of antimicrobial agents Rate, intensity of use, class I perioperative antimicrobial prophylaxis rates declined year by year, while the rate of etiological examination increased year by year. Conclusion: The special rectification activities of antimicrobial agents have obvious effect. After strengthening supervision, the clinical use of antimicrobial agents has been greatly promoted.