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目的观察清热抗毒煎剂联合利巴韦林治疗手足口病普通病例的临床疗效,并探讨其相关机制。方法将120例手足口病普通患儿随机分为治疗组和对照组,每组60例。治疗组给予清热抗毒煎剂联合利巴韦林,对照组单独给予利巴韦林,观察2组的临床疗效。检测2组治疗前后白细胞(WBC)计数、C-反应蛋白(CRP)、血清免疫球蛋白IgA、IgG、IgM及补体C3、C4的含量。结果治疗组症状消退时间短于对照组(P<0.05);治疗组临床有效率高于对照组(P<0.05);治疗后2组血清WBC计数、CRP均有降低,治疗组下调更为明显(P<0.05);治疗后2组血清IgA、IgG表达均有升高,治疗组上调更为明显(P<0.05)。结论清热抗毒煎剂联合利巴韦林治疗手足口病普通病例能够显著提高临床疗效,缩短病程;其机制可能与抑制机体炎性反应、调节机体体液免疫功能相关。
Objective To observe the clinical efficacy of Qingrelingduji decoction combined with ribavirin in the treatment of common cases of hand, foot and mouth disease and to explore its related mechanism. Methods 120 children with HFMD were randomly divided into treatment group and control group, 60 cases in each group. The treatment group was given anti-inflammatory decoction combined with ribavirin, and the control group was given ribavirin alone to observe the clinical efficacy of the two groups. The WBC counts, C-reactive protein (CRP), serum immunoglobulin IgA, IgG, IgM and complement C3 and C4 were measured before and after treatment. Results The symptom regression time in the treatment group was shorter than that in the control group (P <0.05). The clinical effective rate in the treatment group was higher than that in the control group (P <0.05). The WBC count and CRP in the two groups decreased after treatment, (P <0.05). The levels of serum IgA and IgG in the two groups increased after treatment, and the up-regulation in the treatment group was more obvious (P <0.05). Conclusions Qingrelingtang decoction combined with ribavirin in the treatment of common cases of hand, foot and mouth disease can significantly improve the clinical curative effect and shorten the course of the disease. The mechanism may be related to inhibiting the body inflammatory reaction and regulating body fluid immune function.