部分去除肾上腺的大鼠烫伤后,血清糖皮质激素无明显升高,而肝胞液糖皮质激素受体(GR)却有升高的趋势,其中烫伤后6 h组和对照组的相差有非常显著的意义。进一步用打点杂交进行的研究表明,部分去腺大鼠烫伤后6h肝GR mRNA也有增加。这些结果提示,完整动物烫伤时肝胞液GR的减少依赖于血中糖皮质激素的升高。 After partial sclerectomy, there was no significant increase in serum glucocorticoids, but the hepatocytic glucocorticoid receptor (GR) increased. The difference between the 6 h group and the control group was very high. Significant meaning. Further studies using spotting hybridization showed that liver GR mRNA was also increased in 6 hours after scalding in part of glandular rats. These results suggest that the decrease of hepatic cytoplasm GR in intact animals is dependent on the increase of glucocorticoids in blood.