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人和动物的基因组有很大部分由各种内源性病毒组成,它们快速复制和突变,并呈现出时间和空间的变化性,导致或者不导致疾病.但是人类对于其组成、复杂性和动态变化了解不足.迄今为止,高通量基因组学、转录组学和蛋白质组学研究对病毒组-微生物组-人类行为三者之间的相互作用有了一些重要的发现,结果表明其相互作用极大地影响着人体的生理和内稳态.大量的内源性病毒为宿主提供了益处,也带来不良的免疫调节和继发感染.很多寄宿于人体的病毒来源于哺乳动物和鸟类的跨物种传播,这种传播往往导致致死性高的流行病.理解病毒分类以及病毒蛋白质组中负责与宿主病毒组相互作用的元素和因子会帮助我们制订应对未来病毒爆发的策略.本文对病毒宏基因组学研究中与人类健康和疾病相关的一些关键内容进行了综述.“,”A wide array of fast replicating and mutating endogenous viruses with temporal and spatial variability predominate human and zoonotic genomes with and without disease manifestations.However,knowledge about their composition,complexity and dynamics is inadequate.Till date high throughput genomic,transcriptomic and proteomic studies revealed some significant findings on tripartite interaction among virome-microbiome and human behaviors that greatly impact human physiology and homeostasis.Rich repertoires of endogenous viruses provide beneficial attributes to the host,and confer adverse immune modulation and secondary infections.Many of these human inhabiting viruses arise due to cross species transmission from mammals and birds,which leads to lethal epidemics.Comprehension on viral taxonomy,viral proteomic elements and factors responsible for host virome interactions will certainly aid to formulate strategies against future viral outbreaks.The review summarizes some of the key aspects in virome metagenomic studies in correlation with human health and diseases.