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目的探讨新辅助化疗后行手术切除治疗胃癌的临床效果,用以指导胃癌患者尤其中晚期胃癌患者的临床治疗。方法将200例胃癌患者随机分为观察组和对照组各100例。对照组行手术治疗及术后化疗,观察组行新辅助化疗后行手术治疗,统计2组患者的痊愈率、有效率及5年生存率。结果 2组患者的痊愈率比较差异无统计学意义(P>0.05)。观察组的有效率为63%高于对照组的45%,差异有统计学意义(P<0.05)。观察组5年存活62例(62%),对照组存活55例(55%)。2组患者的生存率比较差异无统计学意义(P>0.05)。结论新辅助化疗后行手术治疗胃癌比单纯行胃癌切除术的治疗方法有效率高,但痊愈率及生存率影响不明显。
Objective To investigate the clinical effect of surgical resection of gastric cancer after neoadjuvant chemotherapy to guide the clinical treatment of patients with gastric cancer, especially in patients with advanced gastric cancer. Methods 200 cases of gastric cancer were randomly divided into observation group and control group of 100 cases. The control group underwent surgery and postoperative chemotherapy. The observation group underwent neoadjuvant chemotherapy and then operated. The cure rate, effective rate and 5-year survival rate of the two groups were calculated. Results There was no significant difference in cure rate between the two groups (P> 0.05). The effective rate of the observation group was 63% higher than that of the control group (45%), the difference was statistically significant (P <0.05). In the observation group, 62 patients (62%) survived 5 years and 55 patients (55%) survived in the control group. There was no significant difference in survival rate between the two groups (P> 0.05). Conclusion Surgical treatment of gastric cancer after neoadjuvant chemotherapy is more effective than simple gastric resection, but the effect of cure rate and survival rate is not obvious.