细胞粘附分子(CAM)在炎症反应中起着关键的作用。选择素(selectins)、整合蛋白(integrins)和免疫球蛋白(Ig)基因超家族粘附受体介导着白细胞自血流向炎症聚集处迁移的不同阶段。激活的内皮细胞可促使细胞粘附分子的表达并触发内皮细胞与白细胞的反应。选择素在白细胞与活性内皮细胞最初的相互作用阶段起效(缠绕或滚动),而整合蛋白和Ig超家族的CAM则使这些细胞的粘附牢固并促使其渗出。在滚动过程中,白细胞则被CAM和化学促活受体产生的细胞内信号激活。因此,阻断CAM的功能或其表达已成为治疗炎症疾病的一个新途径。有多种药物(如阿司 Cell adhesion molecule (CAM) plays a key role in the inflammatory response. Selectins, integrins and immunoglobulin (Ig) superfamily adhesion receptors mediate the different stages of leukocyte migration from the bloodstream to the site of inflammation. Activated endothelial cells can promote the expression of cell adhesion molecules and trigger the reaction of endothelial cells with leukocytes. Selectins work (entangle or roll) during the initial interaction of leukocytes with active endothelial cells, whereas the integrins and Ig superfamily CAMs make these cells stick and promote their exudation. During the rolling process, leukocytes are activated by intracellular signals produced by CAMs and chemically activated receptors. Therefore, blocking CAM function or its expression has become a new approach to the treatment of inflammatory diseases. There are a variety of drugs (such as Asi