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目的 探讨Mirrizzi综合征与胆囊癌之间的关系。方法 回顾性总结 2 4例Mirrizzi综合征患者的临床及病理学检查结果 ,并与胆石症组比较合并胆囊癌的发生率。结果 Mirrizzi综合征组胆囊癌的患病率明显高于胆石症组 (P <0 .0 0 1) ,且与患者的年龄、病程、肿瘤相关抗原CA199水平密切相关。结论 Mirrizzi综合征易并发胆囊癌 ,尤其对年龄大、病程长、CA199明显增高者应高度怀疑胆囊癌 ;术中行胆囊多点位取材冰冻切片检查有助于确诊。
Objective To investigate the relationship between Mirrizzi syndrome and gallbladder cancer. Methods The clinical and pathological findings of 24 Mirrizzi syndrome patients were retrospectively reviewed. The incidence of gallbladder cancer was compared with that of gallstone disease group. Results The prevalence of gallbladder cancer in Mirrizzi syndrome group was significantly higher than that in gallstone group (P <0.01), and was closely related to the age, course of disease and the level of tumor associated antigen CA199. Conclusion Mirrizzi syndrome complicated with gallbladder cancer, especially for older, longer duration, CA199 was significantly higher gall bladder cancer should be suspected; intraoperative gallbladder multi-point frozen section examination is helpful to confirm.