【摘 要】
：
A series of four novel hydrazine-modified diamine conjugates(7a-b,8a-b)were synthesized and evaluated for cytotoxicity against Melanoma B16,α-difluoromethylomi
【出 处】
：
Chinese Chemical Letters
论文部分内容阅读
A series of four novel hydrazine-modified diamine conjugates(7a-b,8a-b)were synthesized and evaluated for cytotoxicity against Melanoma B16,α-difluoromethylomithine(DFMO)-treated B16,spermidine(SPD)-treated B16,Mouse leukemia L1210 and Hela cell lines.Both the DFMO-B16 and SPD-B16 experiments indicated that conjugates 7a-b and 8a-b could recognize the polyamine transporter(PAT)and enter the cells in part or in whole via PAT,although they were not as efficient as the reference,9- anthracenemethyl homospermidine(1).
A series of four novel hydrazine-modified diamine conjugates (7a-b, 8a-b) were synthesized and evaluated for cytotoxicity against Melanoma B16, α-difluoromethylomithine (DFMO) -treated B16, spermidine (SPD) -treated B16, Mouse leukemia L1210 and Hela cell lines. But the DFMO-B16 and SPD-B16 experiments indicated that the conjugates 7a-b and 8a-b could recognize the polyamine transporter (PAT) and enter the cells in part or in whole via PAT, although they were not as efficient as the reference, 9-anthracenemethyl homospermidine (1).
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