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目的分析叶酸联合依那普利治疗对高同型半胱氨酸血症高血压患者血同型半胱氨酸(Hcy)水平的影响。方法按照随机双盲的原则将高同型半胱氨酸血症高血压患者98例分成试验组和对照组各49例。2组均给予依那普利片治疗,试验组在此基础上给予叶酸治疗。比较2组治疗前后血Hcy水平。结果 2组治疗后血Hcy水平均低于治疗前,且试验组血Hcy水平低于对照组,差异均有统计学意义(P<0.01)。结论叶酸联合依那普利治疗高同型半胱氨酸血症高血压效果良好,可显著降低患者血Hcy水平,值得临床推广应用。
Objective To analyze the effect of folic acid combined with enalapril on blood homocysteine (Hcy) level in hypertensive patients with hyperhomocysteinemia. Methods According to the principle of random double-blind, 98 cases with hyperhomocysteinemia were divided into experimental group and control group with 49 cases each. Both groups were given enalapril treatment, the experimental group was given folic acid on this basis. Blood Hcy levels before and after treatment were compared between the two groups. Results The blood levels of Hcy in both groups were lower than those before treatment, and the level of Hcy in the experimental group was lower than that in the control group (P <0.01). Conclusion Folic acid combined with enalapril treatment of hyperhomocysteinemia with good effect of hypertension, can significantly reduce the blood of patients with Hcy levels, worthy of clinical application.