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目的探讨中国成年人中血清尿酸水平与糖耐量受损(IGT)的关系,评估年龄、性别、体质量指数(BMI)、血压和脂类对该关系的影响。方法以来自江苏徐州地区社区的1 956名健康体检人群为研究对象,检查受试者血压、空腹胰岛素、血脂、血糖等相关生化指标。血清SUA与糖耐量受损的相关指标分析采用单因素方差分析,多变量间的分析采用多元逐步Logistic回归。结果血清尿酸水平按四分位法进行分层,校正多个相关因素后,IGT风险的OR值及95%的可信区间(CI)分别为[1.0,1.406(0.948~2.087),1.469(0.959~2.251),2.352(1.539~3.592),趋势P值<0.001]。血尿酸与甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)交互作用对IGT风险的影响有统计学意义(交互作用P值分别为0.044、0.037)。结论血清尿酸水平与IGT相关联,并独立于其他代谢危险因素。高水平TG及LDL-C可增强这种相关性。
Objective To investigate the relationship between serum uric acid level and impaired glucose tolerance (IGT) in Chinese adults and to evaluate the effect of age, sex, body mass index (BMI), blood pressure and lipid on the relationship. Methods A total of 1 956 healthy people from Xuzhou community were enrolled in this study. Blood pressure, fasting insulin, blood lipids, blood glucose and other related biochemical parameters were examined. Correlation analysis between serum SUA and impaired glucose tolerance was performed by one-way analysis of variance (ANOVA) and multivariate stepwise logistic regression was used for multivariate analysis. Results Serum uric acid levels were stratified by quartile method. After adjusting for a number of related factors, the OR of IGT risk and 95% confidence interval (CI) were [1.0,1.406 (0.948-2.087), 1.469 (0.959 ~ 2.251), 2.352 (1.539 ~ 3.592), trend P value <0.001]. Interaction between serum uric acid and triglyceride (TG) and low density lipoprotein cholesterol (LDL-C) had a significant effect on the risk of IGT (P = 0.044,0.037, respectively). Conclusions Serum uric acid level is associated with IGT and is independent of other metabolic risk factors. High levels of TG and LDL-C enhance this correlation.