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目的探讨2型糖尿病(T2DM)患者糖基化血红蛋白(HbA1c)水平与血脂的相关性。方法检测949例住院的T2DM患者隔夜空腹10h血HbA1c、空腹血糖(FBG)、餐后2-h血糖(PBG)、血清总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)。结果女性T2DM患者TC、TG和HDL-C均高于男性T2DM患者(P<0.01或P<0.05)。HbA1c与FBG、PBG有显著的相关性(P<0.01)。HbA1c与TC、TG、LDL-C呈显著正相关(P<0.01)。血糖控制差(6.5%9%)组的TC、TG和LDL-C显著高于血糖控制好组(HbA1c≤6.5%)。结论T2DM患者血糖水平与脂代谢紊乱密切相关。HbA1c不仅是反映血糖控制的生化指标,而且也可以预示脂代谢的紊乱。
Objective To investigate the correlation between serum HbA1c and blood lipids in type 2 diabetes mellitus (T2DM). Methods The serum levels of HbA1c, fasting blood glucose (FBG), postprandial 2-h blood glucose (PBG), serum total cholesterol (TC), triglyceride (TG) and high density lipoprotein cholesterol HDL-C), low-density lipoprotein cholesterol (LDL-C). Results The levels of TC, TG and HDL-C in female T2DM patients were higher than those in male T2DM patients (P <0.01 or P <0.05). There was a significant correlation between HbA1c and FBG and PBG (P <0.01). There was a significant positive correlation between HbA1c and TC, TG and LDL-C (P <0.01). TC, TG and LDL-C of poor glycemic control (6.5% 9%) were significantly higher than those of the control group (HbA1c≤6.5%). Conclusion The blood glucose level in T2DM patients is closely related to the disorder of lipid metabolism. HbA1c is not only a biochemical indicator of glycemic control but can also indicate disorders of lipid metabolism.