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目的探讨胃癌术后同步放化疗的疗效与血清血管内皮生长因子(VEGF)水平的关系。方法回顾性分析2010年1月-2011年6月来该院就诊的胃癌术后同步放化疗患者200例的临床资料,根据1年和3年生存率分为高生存率组和低生存率组,各100例。通过查阅病史统计化疗前后2组患者血清血管内皮生长因子(VEGF)水平,比较其差异。结果 2组患者治疗前血清VEGF水平相近,差异无统计学意义(P>0.05)。治疗后2组患者血清VEGF水平均有所降低,但高生存率组血清VEGF水平显著低于低生存率组,差异有统计学意义(P<0.05)。结论相同治疗条件下血清VEGF水平较高的患者预后生存率较低。
Objective To investigate the relationship between curative effect of concurrent chemoradiotherapy and serum vascular endothelial growth factor (VEGF) level after gastric cancer surgery. Methods The clinical data of 200 patients with postoperative concurrent chemoradiotherapy of gastric cancer treated in our hospital from January 2010 to June 2011 were retrospectively analyzed. According to the 1 year and 3 year survival rates, the patients were divided into high survival rate group and low survival rate group , Each 100 cases. The levels of serum vascular endothelial growth factor (VEGF) were compared between the two groups before and after chemotherapy, and the differences were compared. Results The serum VEGF levels of two groups before treatment were similar, with no significant difference (P> 0.05). Serum VEGF levels decreased in both groups after treatment, but serum VEGF levels in the high survival group were significantly lower than those in the low survival group (P <0.05). Conclusions Patients with higher serum VEGF levels under the same treatment conditions have a lower prognostic survival rate.