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目的探讨紫杉醇联合顺铂同步放疗、化疗治疗中晚期宫颈鳞癌的临床疗效。方法选取2012年2月—2015年2月洛阳市第三人民医院收治的中晚期宫颈鳞癌患者37例,均采用紫杉醇联合顺铂同步放疗、化疗治疗。观察患者临床疗效及毒副作用(骨髓抑制、胃肠道反应、放射性肠炎、肝功能异常、肾功能异常、放射性膀胱炎)发生情况。结果治疗后3个月,患者完全缓解20例、部分缓解14例、病变稳定2例、病变进展1例,总有效率为91.9%;均未发生严重毒副作用。结论紫杉醇联合顺铂同步放疗、化疗治疗中晚期宫颈鳞癌的临床疗效显著,可有效提高患者近期疗效,安全性高。
Objective To investigate the clinical efficacy of paclitaxel plus cisplatin in combination with concurrent radiotherapy and chemotherapy for advanced cervical squamous cell carcinoma. Methods A total of 37 patients with advanced squamous cell carcinoma of the cervix who were admitted to the Third People’s Hospital of Luoyang from February 2012 to February 2015 were treated with paclitaxel combined with cisplatin simultaneously with chemotherapy. To observe the clinical efficacy and side effects (bone marrow suppression, gastrointestinal reactions, radiation enteritis, abnormal liver function, renal dysfunction, radiation cystitis) occurred. Results Three months after treatment, 20 cases were completely relieved, 14 cases partially relieved, 2 cases stable, and 1 case showed pathological changes. The total effective rate was 91.9%. No serious toxic or side effects occurred. Conclusions Paclitaxel plus cisplatin combined with concurrent radiotherapy and chemotherapy in the treatment of advanced cervical squamous cell carcinoma clinical efficacy was significant, which can effectively improve the short-term efficacy of patients with high safety.