论文部分内容阅读
目的:探讨熊去氧胆酸治疗早产儿胃肠外营养相关性胆汁淤积症的疗效及对患儿血清内毒素水平的影响。方法:选自2013年1月—2015年12月期间我院收治的胃肠外营养相关性胆汁淤积症早产儿64例,依据随机数字表法随机分为观察组32例与对照组32例。对照组采取常规对症治疗,观察组在对照组基础上结合熊去氧胆酸胶囊。两组疗程均为2周。比较两组患儿肝功能指标水平变化,以及不良反应发生情况。结果:两组血清TB、ALT、AST水平治疗前比较无统计学差异(P>0.05);两组血清TB、ALT、AST水平治疗后明显降低(P<0.05);观察组血清TB、ALT、AST水平治疗后低于对照组(P<0.05);两组血清内毒素水平治疗前比较无统计学差异(P>0.05);两组血清内毒素水平治疗后明显降低(P<0.05);观察组血清内毒素水平治疗后低于对照组(P<0.05);两组不良反应发生率比较无统计学差异(P>0.05)。结论:熊去氧胆酸治疗早产儿胃肠外营养相关性胆汁淤积症的效果明显,可明显改善患儿肝功能,降低血清内毒素水平,具有重要临床研究价值。
Objective: To investigate the efficacy of ursodeoxycholic acid in the treatment of preterm infants with parenteral nutrition-related cholestasis and its effect on serum endotoxin levels in children. Methods: 64 cases of preterm infants with parenteral nutrition-related cholestasis admitted to our hospital from January 2013 to December 2015 were randomly divided into observation group (32 cases) and control group (32 cases) according to the random number table method. Control group to take conventional symptomatic treatment, the observation group in the control group combined with ursodeoxycholic acid capsules. Two groups of treatment are 2 weeks. The changes of liver function indexes and the incidence of adverse reactions in both groups were compared. Results: Serum levels of TB, ALT and AST were not significantly different between the two groups before treatment (P> 0.05). Serum levels of TB, ALT and AST were significantly decreased in both groups (P <0.05) (P <0.05). There was no significant difference in serum endotoxin levels between the two groups before treatment (P> 0.05). The levels of endotoxin in both groups were significantly lower after treatment (P <0.05) The level of serum endotoxin was lower than that of the control group (P <0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P> 0.05). Conclusion: Ursodeoxycholic acid treatment of preterm children with parenteral nutrition-related cholestasis obvious effect, can significantly improve children’s liver function, reduce serum endotoxin levels, has important clinical research value.