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目的明确东营市HPV疫情的分布,对疫苗的开发和引进进行指导。方法采用基因导流杂交技术,对5 334名健康体检妇女宫颈脱落细胞中的21种HPV亚型进行检测,对人群感染率、各HPV亚型分布及各年龄段HPV感染率等指标进行统计分析。结果在5 334例样本中,HPV总感染率为15.05%(803/5 334);各HPV亚型感染率前4位依次是HPV-16、52、58、53型,占到总感染株的59.38%(566/953);≤30岁年龄段HPV感染率20.83%显著高于31~40岁(15.27%)、41~50岁(14.34%)和≥51岁(16.15%)年龄段的感染率(P﹤0.01)。结论各地区应根据当地HPV亚型的流行情况有针对性的开发引进HPV疫苗,就东营市而言,可针对青春期和青春前期女性开发引进以HPV-16、52、58、53亚型为主的HPV预防性疫苗。
Objective To clarify the distribution of HPV epidemic in Dongying City and to guide the development and introduction of vaccines. Methods Gene-flow-mediated hybridization was used to detect 21 HPV subtypes in 5 334 cervical exfoliated cells in healthy women. The infection rates, the distribution of HPV subtypes and HPV infection rate among different age groups were statistically analyzed . Results Among the 5 334 samples, the total HPV infection rate was 15.05% (803/5 334). The top 4 infection rates of each HPV subtype were HPV-16, 52, 58 and 53, accounting for 59.38% (566/953). The infection rate of 20.83% ≤30 years old was significantly higher than that of 31 ~ 40 years old (15.27%), 41 ~ 50 years old (14.34%) and ≥51 years old (16.15% Rate (P <0.01). Conclusion The HPV vaccines should be developed and targeted according to the local prevalence of HPV subtypes in different regions. For Dongying City, HPV-16, 52, 58 and 53 subtypes could be introduced mainly for adolescent and pre-adolescent female development HPV preventive vaccine.