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我们已发现外源性催产素能改善人及豚鼠以恼干电位或耳蜗电图为指标的听觉功能。本文在对照组和预先给予催产素处理的豚鼠上,比较了125dB(SPL)白噪声暴露20min前后声音强度辨别能力的改变,并比较了肌内注射和侧脑室微量注射两种不同给药途径的作用。实验以重复短声调幅引起的皮层慢反应电位阈值I_r为指标,观察了催产素对豚鼠声音强度辨别功能的影响。结果发现对照组噪声暴露所致I_r的升高明显高于催产素处理组,且此种暂时性阈移的恢复也明显慢于催产素组;催产素两种给药途径的结果无明显差异。这些结果进一步提示催产素对声音强度辨别功能具有保护作用。
We have found that exogenous oxytocin improves the auditory function of people and guinea pigs that are sensitive to electrical potential or to the electrocochleogram. In this study, we compared the changes of sound intensity before and after exposure to 125 dB (SPL) white noise in control and oxytocin-treated guinea pigs and compared two different routes of intramuscular injection and intracerebroventricular microinjection effect. In this study, the effect of oxytocin on the discrimination of the sound intensity of guinea pigs was observed by using the threshold I_r of cortical hypodermic response induced by repeated short-tone amplitude modulation. The results showed that the control group caused by noise exposure increased I_r was significantly higher than the oxytocin treatment group, and this temporary threshold recovery was significantly slower than the oxytocin group; oxytocin two routes of administration showed no significant difference. These results further suggest that oxytocin has a protective effect on sound intensity discrimination.