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纳米生物技术为重大疾病的精确诊断和高效治疗提供了全新、高效和多样化的途径.新型生物材料体系的开发是实现纳米生物技术临床转化、病人个人化治疗、从而造福病人的关键要素之一.作为新的无机材料体系,介孔碳生物材料(MCBs)结合了介孔纳米结构和碳组成的优点,与介孔氧化硅和碳基纳米材料(如石墨烯、碳纳米管、富勒烯)相比,在生物医学领域展现出更多的优点.这篇综述重点阐述了MCBs的设计、化学合成以及在生物医学领域中的应用进展.论文首先总结了MCBs,特别是介孔碳纳米颗粒(MCNs)的制备方法.随后详细地综述了MCBs在可控药物释放、光热治疗、协同治疗、荧光细胞标记、人体有毒物质的生物吸附、肽分离和生物传感中的应用.在此基础上,初步讨论了MCBs的生物安全性.由于MCBs具有特殊的纳米结构、化学组成和良好的生物相容性,一旦目前MCBs面临的几个难题得到圆满解决,我们有理由相信其在不久的将来会实现临床转化和应用.
Nanobiotechnology provides a new, efficient and diversified approach to the precise diagnosis and efficient treatment of major diseases.Development of a new biomaterial system is one of the key elements to bring about the clinical transformation of the nano-biotechnologies and the personalized treatment of the patients to benefit the patients As a new inorganic material system, mesoporous carbon biomaterials (MCBs) combine the advantages of mesoporous nanostructures and carbon compositions with the advantages of mesoporous silica and carbon-based nanomaterials such as graphene, carbon nanotubes, fullerenes ), This review focuses on the design, chemical synthesis and application of MCBs in the field of biomedicine.The paper first summarizes the properties of MCBs, especially mesoporous carbon nanoparticles (MCNs) .Afterwards, the application of MCBs in controlled drug release, photothermal therapy, synergistic therapy, fluorescent cell labeling, bioabsorption of human toxic substances, peptide separation and bio-sensing was reviewed in detail. , Initially discussed the biological safety of MCBs.Because MCBs have a special nanostructure, chemical composition and good biocompatibility, once the current MCBs face Several problems satisfactorily resolved, we have reason to believe it will achieve clinical transformation and application in the near future.